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Peter J. Gebicke-Haerter, Prof. Dr.
Anschrift : Zentralinstitut für Seelische Gesundheit
Abteilung : Psychopharmakologie
Leitung: Prof. Dr. Rainer Spanagel
J5
68159 Mannheim
Telefon : 06 21 / 1703-6256
Fax : 06 21 / 1703-6255
Email : peter.gebicke@zi-mannheim.de
Liste der wissenschaftlichen Veröffentlichungen (ab 1995)
1. K. Appel, P. Honegger, P.J. Gebicke-Haerter (1995) Expression of interleukin-3 and tumor necrosis factor-b mRNAs in cultured microglia. J.Neuroimmunol. 60, 83-91.
2. J. Norgauer, F. Bartels, U. Göhring, E. Schöpf, P.J. Gebicke-Haerter, E. Kownatzki, J. Krutmann (1995) Expression of intercellular adhesion molecule-1 is regulated by the actin network in epidermoid carcinoma cells. Exp.Cell Res. 219, 15-20.
3. K. Appel, M. Buttini, A. Sauter, P.J. Gebicke-Haerter (1995) Cloning of rat interleukin-3 receptor b-subunit from cultured microglia and its mRNA expression in vivo. J.Neurosci. 15, 5800 -5809.
4. M. Buttini, K. Appel, A. Sauter, P.J. Gebicke-Haerter, H.W.G.M. Boddeke (1996) Expression of tumor necrosis factor alpha after focal cerebral ischaemia in the rat. Neuroscience 71, 1-16.
5. P.J. Gebicke-Haerter, F. Christoffel, J. Timmer, H. Northoff, M. Berger, D. van Calker (1996) Both adenosine A1- and A2-receptors are required to stimulate microglial proliferation. Neurochem. Int. 29, 37-42.
6. M. Bohus, U. Förstner, C. Kiefer, P.J. Gebicke-Haerter, J. Timmer, G. Spraul, H.-J. Wark, H. Hecht, M. Berger, D. van Calker (1996) Increased sensitivity of the inositol-phospholipid system in neutrophils from patients with acute major depressive episodes. Psych. Res. 65, 45-51.
7. K. Biber, J. Walden, P.J. Gebicke-Haerter, M. Berger, D. van Calker (1996) Carbamazepine inhibits the potentiation by adenosine analogues of agonist induced inositol phosphate formation in hippocampal astrocyte cultures. Biol.Psych. 40, 563-567.
8. B. L. Fiebich, K. Biber, K. Lieb, D. van Calker, M. Berger, J. Bauer, P.J. Gebicke-Haerter (1996) Cyclooxygenase-2 expression in rat microglia is induced by adenosine A2a-receptors. Glia 18, 152-160.
9. M. K. A. Bauer, K. Lieb, K. Schulze-Osthoff, M. Berger, P.J. Gebicke-Haerter, J. Bauer, B. L. Fiebich (1997) Expression and regulation of cyclooxygenase-2 in rat microglia. Eur.J.Biochem. 243, 726-731.
10. G. Queiroz, P.J. Gebicke-Haerter, A. Schobert, K. Starke, I. von Kügelgen (1997) Release of ATP from cultured rat astrocytes elicited by glutamate receptor activation. Neuroscience 78, 1203-1208.
11. K. Biber, P.J. Gebicke-Haerter, M. Berger, D. van Calker (1997) The coupling of adenosine A1-receptors to different second-messenger systems in cultured astrocytes depends on the level of receptor mRNA. J.Neurosci. 17, 4956-4964.
12. M. Buttini, A. Mir, K. Appel, K.H. Wiederhold, S. Limonta, P.J. Gebicke-Haerter, H.W.G.M. Boddeke (1997) Lipopolysaccharide induces expression of tumor necrosis factor-a in rat brain : modulation by methylprednisolone and by rolipram. Br.J.Pharmacol. 122, 1483-1489.
13. O. Spleiss, N. Gourmala, H.W.G.M. Boddeke, A. Sauter, B. L. Fiebich, M. Berger, P. J. Gebicke-Haerter (1998) Cloning of rat HIV1-chemokine co-receptor CKR5 from microglia and upregulation of its mRNA in ischemic and endotoxinemic rat brain. J. Neurosci. Res. 53, 16-28.
14. L.-Q. Ren, N. Gourmala, H.W.G.M. Boddeke, P.J. Gebicke-Haerter (1998) LPS-induced expression of IP-10 mRNA in rat brain and in cultured rat astrocytes and microglia. Mol.Brain Res. 59, 256-263
15. O. Spleiss, D. van Calker, L. Schärer, K. Adamovic, M. Berger, P.J. Gebicke-Haerter (1998) Abnormal G protein as- and ai2-subunit mRNA expression in bipolar affective disorder. Mol.Psychiatry 3, 512-520.
16. B. Ibach, K. Appel, P.J. Gebicke-Haerter, R.P. Meier, T. Friedberg, R. Knoth, B. Volk (1998) Cytochrome P450 2B1 mRNA expression and regulation in primary rat glial cultures. J.Neurosci.Res. 54, 402-411.
17. B.L. Fiebich, R.D. Butcher, P.J. Gebicke-Haerter (1998) Protein kinase C-mediated regulation of inducible nitric oxide synthase expression in cultured microglial cells. J.Neuroimmunol. 92, 170-178.
18. Y. Kitamura, T. Ota, Y. Matsuoka, M. Okazaki, J.-I. Kakimura, I. Tooyama, H. Kimura, S. Shimohama, P.J. Gebicke-Haerter, Y. Nomura, T. Taniguchi (1998) Kainic acid-induced neuronal loss and glial changes in the hippocampal CA3 of p53-deficient mouse. Neurosci. Lett. 255, 57-60.
19. B. M. Küst, K. Biber, D. van Calker, P.J. Gebicke-Haerter (1999) Regulation of K+ channel mRNA expression by stimulation of adenosine A2A-receptors in cultured rat microglia. Glia 25, 120-130.
20. Y. Kitamura, T. Ota, Y. Matsuoka, I. Tooyama, H. Kimura, S. Shimohama, Y. Nomura, P.J. Gebicke-Haerter, T. Taniguchi (1999) Hydrogen peroxide-induced apoptosis mediated by p53 protein in glial cells. Glia 25, 154-164.
21. K. Biber, B.L. Fiebich, P.J. Gebicke-Haerter, M. Berger, D. van Calker (1999) Carbamazepine-induced upregulation of adenosine A1-receptors in astrocyte cultures affects coupling to the phosphoinositol signaling pathway. Neuropsychopharmacology 20, 271-278.
22. L.-Q. Ren, B. Lubrich, K. Biber, M. Berger, P.J. Gebicke-Haerter (1999) Differential expression of inflammatory mediators in rat microglia cultured from different brain regions. Molec.Brain Res. 65, 198-205.
23. Y. Matsuoka, Y. Kitamura, H. Takahashi, I. Tooyama, H. Kimura, P.J. Gebicke-Haerter, Y. Nomura, T. Taniguchi (1999) Interferon-g plus lipopolysaccharide induction of delayed neuronal apoptosis in rat hippocampus. Neurochem.Int. 34, 91-99.
24. Y. Kitamura, S. Shimohama, H. Koike, J.-I. Kakimura, Y. Matsuoka, Y. Nomura, P.J. Gebicke-Haerter, T. Taniguchi (1999) Increased expression of cyclooxygenases and peroxisome proliferator-activated receptor-g in Alzheimer´s disease brains. Biochem.Biophys.Res.Commun. 254, 582-586.
25. Y. Kitamura, J.-I. Kakimura, Y. Matsuoka, Y. Nomura, P.J. Gebicke-Haerter, T. Taniguchi (1999) Activators of peroxisome proliferator-activated receptor-g inhibit inducible NO synthase expression but increase heme oxygenase-1 expression in rat glial cells. Neurosci. Lett. 262, 129-132.
26. K. Biber, D.J. Laurie, A. Berthele, B. Sommer, T. R. Tölle, P.J. Gebicke-Haerter, D. van Calker, H.W.G.M. Boddeke (1999) Expression and signaling of group I metabotropic glutamate receptors in astrocytes and microglia. J.Neurochem. 72, 1671-1680.
27. H.W.G.M. Boddeke, I. Meigel, S. Frentzel, N. Gourmala, J.K. Harrison, M. Buttini, O. Spleiss, P.J. Gebicke-Haerter (1999) Cultured rat microglia express functional b-chemokine receptors. J.Neuroimmunol. 98, 176-184.
28. H.W.G.M. Boddeke, I. Meigel, S. Frentzel, K. Biber, L.-Q. Ren, P.J. Gebicke-Haerter (1999) Functional expression of the fractalkine (CX3C) receptor and its regulation by lipopolysaccharide in rat microglia. Eur.J.Pharmacol. 374, 309-313.
29. B. Lubrich, O. Spleiss, P.J. Gebicke-Haerter, D. van Calker (2000) Differential expression, activity and regulation of the sodium/myo-inositol cotransporter in astrocyte cultures from different regions of the rat brain. Neuropharmacology 39, 680-690.
30. Y. Kitamura, T. Taniguchi, H. Kimura, Y. Nomura, P.J. Gebicke-Haerter (2000) Interleukin-4-inhibited mRNA expression in mixed astrocyte and isolated rat microglial cultures. J.Neuroimmunology 106, 95-104.
31. S. Dichmann, H. Rheinen, E. Panther, Y. Herouy, W. Czech, C. Termeer, J.C. Simon, P.J. Gebicke-Haerter, J. Norgauer (2000) Downregulation of platelet activating factor responsiveness during maturation of human dendritic cells. J.Cell.Physiol. 185, 394-400.
32. Y. Kitamura, J.-I. Kakimura, H. Koike, M. Umeki, P.J. Gebicke-Haerter, Y. Nomura, T. Taniguchi (2001) Effects of 15-deoxy-D12,14 prostaglandin J2 and interleukin-4 in Toll-like receptor-4-mutant glial cells. Eur.J.Pharmacol. 411, 223-230.
33. J.-I. Kakimura, Y. Kitamura, T. Taniguchi, S. Shimohama, P.J. Gebicke-Haerter (2001) BiP/GRP78-induced production of cytokines and uptake of amyloid-b(1-42) peptide in microglia. Biochem.Biophys.Res.Commun. 281, 6-10.
34. Y. Kitamura, O. Spleiss, T. Taniguchi, H. Kimura, Y. Nomura, P. J. Gebicke-Haerter (2001) Lipopolysaccharide-induced switch between retinoid receptor (RxR) a and glucocorticoid attenuated response gene (GARG) – 16 messenger RNAs in cultured rat microglia. J.Neurosci.Res. 64, 553-563.
35. S. Dichmann, Y. Herouy, D. Purlis, H. Rheinen, P.J. Gebicke-Haerter, J. Norgauer (2001) Fractalkine induces chemotaxis and actin polymerization in human dendritic cells. Inflamm. Res. 50, 529-533.
36. E. Panther, M. Idzko, D. Purlis, Y. Herouy, H. Rheinen, P. Gebicke-Haerter, U. Mrowietz, S. Dichmann, J. Norgauer (2001) Expression and function of adenosine receptors in human dendritic cells. FASEB J. 15, 1963-1970.
37. M. Idzko, E. Panther, S. Corinti, A. Morelli, D. Ferrari, Y. Herouy, S. Dichmann, M. Mockenhaupt, P. Gebicke-Haerter, F. di Virgilio, G. Girolomoni, J. Norgauer (2002) Sphingosine 1-phosphate induces chemotaxis of immature dendritic cells and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses. FASEB J. 16, 625-627.
38. J.-I. Kakimura, Y. Kitamura, K. Takata, M. Umeki, S. Suzuki, K. Shibagaki, T. Taniguchi, Y. Nomura, P.J. Gebicke-Haerter, M.A. Smith, G. Perry, S. Shimohama (2002) Microglial activation and amyloid-b clearance induced by exogenous heat-shock proteins. FASEB J. 16, 601-603.
39. E. Panther, M. Idzko, S. Corinti, D. Ferrari, V. Herouy, M. Mockenhaupt, S. Dichmann, P. Gebicke-Haerter, F. di Virgilio, G. Girolomoni, J. Norgauer (2002) The influence of lysophosphatidic acid on the functions of human dendritic cells. J Immunol. 169, 4129-35.
40. J. Kakimura, Y. Kitamura, K. Takata, D. Tsuchiya, T. Taniguchi, P.J. Gebicke-Haerter, M.A. Smith, G. Perry, S. Shimohama (2002) Possible involvement of ER chaperone Grp78 on reduced formation of amyloid-b deposits. Ann.N.Y.Acad.Sci. 977, 327-332.
41. K. Takata, Y. Kitamura, J. Kakimura, K. Shibagaki, T. Taniguchi, P.J. Gebicke-Haerter, M.A. Smith, G. Perry, S. Shimohama (2002) Possible protective mechanisms of heme oxygenase-1 in the brain. Ann.N.Y.Acad.Sci. 977, 501-506.
42. Y. Kitamura, K. Shibagaki, K. Takata, D. Tsuchiya, T. Taniguchi, P.J. Gebicke-Haerter, H. Miki, T. Takenawa, S. Shimohama (2003) Involvement of Wiskott-Aldrich syndrome protein family verprolin-homologous protein (WAVE) and Rac1 in the phagocytosis of amyloid-beta(1 - 42) in rat microglia. J Pharmacol Sci. 92,115-123.
43. K. Takata, Y. Kitamura, M. Umeki, D. Tsuchiya, J. Kakimura, T. Taniguchi, P.J. Gebicke-Haerter, S. Shimohama (2003) Possible involvement of small oligomers of amyloid-beta peptides in 15-deoxy-Delta12,14 prostaglandin J2-sensitive microglial activation. J Pharmacol Sci. 91, 330-333.
44. F. Leonardi-Essmann, M. Emig, Y. Kitamura, R. Spanagel, P.J. Gebicke-Haerter (2005) Fractalkine-upregulated milk-fat globule EGF factor-8 (MFG-E8) protein in cultured rat microglia. J. Neuroimmunol. 160, 92-101.
45. R. S.Akundi, E. Candelario-Jalil, S. Hess, M. Hüll, K. Lieb, P.J. Gebicke-Haerter, B.L. Fiebich (2005) Involvement of mitogen-activated protein kinases and sphingomyelinase in lipopolysaccharide-induced rat microglial cells. Glia 51, 199-208.
46. M. Zink, S. Rapp, P.J. Gebicke-Haerter, F.A. Henn, J. Thome (2005) Antidepressants differentially affect expression of complexin I and II RNA in rat hippocampus. Psychopharmacology 181,560-565.
47. D. Zieker, E. Fehrenbach, J. Dietzsch, J. Fliegner, M. Waidmann, K. Nieselt, P.J. Gebicke-Haerter, R. Spanagel, P. Simon, A.M. Niess, H. Northoff (2005) cDNA-microarray analysis reveals novel candidate genes expressed in human peripheral blood following exhaustive exercise. Physiol. Genomics 23, 287-294.
48. J. Zieker, D. Zieker, A. Jatzko, J. Dietzsch, K. Nieselt, A. Schmitt, T. Bertsch, K. Fassbender, R. Spanagel, H. Northoff and P.J. Gebicke-Haerter (2007) Differential gene expression in peripheral blood of patients suffering from Posttraumatic Stress Disorder. Molec. Psychiatry 12, 116-118.
49. V. Vengeliene, F. Leonardi-Essmann, S. Perreau-Lenz, P. Gebicke-Haerter, K. Drescher, G. Gross, R. Spanagel (2007) The dopamine D3 receptor plays an essential role in alcohol-seeking and relapse. FASEB J. 20, 2223-2233.
51. M. Zink, B. Vollmayr, P.J. Gebicke-Haerter, F.A. Henn, J. Thome (2007) Reduced expression of complexin I and II in rats bred for learned helplessness. Brain Res. 1144, 202-208.
52. P. Gass, F. Leonardi-Essmann, M. Zueger, R. Spanagel, P. J. Gebicke-Haerter (2008) Transcriptional changes in insulin- and lipid metabolism-related genes in the hippocampus of olfactory bulbectomized mice. J. Neurosci. Res., in press.
53. M. Zink, B. Vollmayr, P.J. Gebicke-Härter, F.A. Henn (2008) Reduced expression of glutamate transporters vGluT1, EAAT2 and EAAT4 in learned helpless rats, an animal model of depression. Neuropsychopharmacology, subm.
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54. M. Zink, B. Vollmayr, P.J. Gebicke-Haerter, F.A. Henn (2008) Reduced expression of GABA transporter GAT3 in learned helpless rats, an animal model of depression. subm.
55. N. Segnitz, A. Schmitt, P.J. Gebicke-Härter, M. Zink (2008) Differential expression of glutamate transporter genes after chronic oral treatment of rats with aripiprazole.
Liste der Buchbeiträge und Reviews
1. D. van Calker, M. Bohus, P.J. Gebicke-Haerter, H. Hecht, H.-J. Wark, M. Berger (1995) Sensitivität des Inositolphosphat/ Ca2+-second messenger Systems bei affektiven Störungen. Pathogenetischer Faktor und Angriffspunkt prophylaktischer Lithiumtherapie ? IN : Aktuelle Perspektiven der Biologischen Psychiatrie 1994 (H.-J. Möller, F. Müller-Spahn, G. Kurtz (eds.)), Springer Verlag, Wien, pp. 778-782.
2. P.J. Gebicke-Haerter, D. van Calker, P. Illes (1996) Molecular mechanisms of microglial activation. A. Implications for regeneration and neurodegenerative diseases. Neurochem.Int. 29, 1-12.
3. P. Illes, W. Nörenberg, P.J. Gebicke-Haerter (1996) Molecular mechanisms of microglial activation. B. Voltage- and purinoceptor-operated channels in microglia. Neurochem.Int. 29, 13-24.
4. P.J. Gebicke-Haerter, D. van Calker, W. Nörenberg, P.Illes (1996) Ionic and molecular events in the course of microglial activation. Fair or foul for health or disease ? In "Topical issues in microglia research" (ed. by E.A. Ling & C.-K. Tan, Singapore Neurosci. Association), pp. 143-164.
5. B. Küst, M. Buttini, A. Sauter, H.W.G.M. Boddeke, P.J. Gebicke-Haerter (1997) K+-channels and cytokines as markers for microglial activation. IN: "Brain plasticity : development and aging" (G. Filogamo, A. Vernadakis, F. Gremo, A. Privat, P.S. Timiras (eds.)) Plenum Press, New York, vol. 429, pp 109-117.
6. B. Küst, K. Appel, M. Buttini, A. Sauter, H.W.G.M. Boddeke, M. Berger, D. van Calker, P.J. Gebicke-Haerter (1997) Molecular determinants of microglial activation stages. IN : Proc.Eur.Soc. Neurochem. : Neurochemistry : Cellular, Molecular, and Clinical Aspects, (A. Teelken, J. Korf, eds.), pp. 535-539.
7. P. J. Gebicke-Haerter, K. Appel, H. W.G.M. Boddeke, M. Berger, O. Spleiss (1998) Molecular biology of microglia cytokine and chemokine receptors and microglial activation. Life Sciences 62, 1707-1710.
8. P.J. Gebicke-Haerter, P. Illes, K. Lieb, M. Berger (1998) Mikroglia: Mechanismen der Aktivierung und Bedeutung bei der Pathogenese neuropsychiatrischer Erkrankungen. Nervenarzt 69, 752-762.
9. D. van Calker, K. Biber, J. Walden, P.J. Gebicke-Haerter, M. Berger (2000) Carbamazepine and adenosine receptors. IN: Bipolar Medications - Mechanism of action (H. K. Manji, C. Bowden, R. H. Belmaker, eds.) pp. 331-346; American Psychiatric Press Inc. Washington, London.
10. P.J. Gebicke-Haerter, O. Spleiss, L.-Q. Ren, H. Li, S. Dichmann, J. Norgauer, H.W.G.M. Boddeke (2001) Microglial chemokines and chemokine receptors. In : " Glial Cell Function " Progr. in Brain Research 132, 535-542. Elsevier Science Publ.
11. P.J. Gebicke-Haerter (2001) " Microglia in Neurodegeneration : Molecular Aspects " In : "Studies on microglia in vitro" - Microscopy Research and Technique (Micr. Res. Tech.) 54: 47-58. - (Johnson JE, ed.) John Wiley, N.Y., N.Y.
12. Y. Kitamura, J.-I. Kakimura, T. Taniguchi, S. Shimohama, P.J. Gebicke-Haerter (2002) BiP/GRP78-induced microglial activation and increase of Ab clearance. IN : „Mapping the Progress of Alzheimer´s and Parkinson´s Disease” (Mizuno et al. eds.) Kluwer Academic/Plenum Publishers, pp. 235-238.
13. R. Spanagel, P. Gebicke-Haerter (2003) Der Sucht auf der Spur. Biochip-Untersuchungen bieten erste Hinweise auf Kandidatengene. In : „ZI Information aktuell“ Nr. 1, September 2003, pp. 31-32.
14. P. Gebicke-Haerter, R. Spanagel (2004) Neuropharmakologie der Sucht. In: Suchtberatung in der Apotheke (C. Fahrmbacher-Lutz, ed.). Dt. Apotheker Verlag, Stuttgart, pp. 22-30.
15. P. J. Gebicke-Haerter and W. H. Sommer (2005) Editorial: DNA microarrays and expression profiling in drug abuse research. Addiction Biol.10, 1-3.
16. P. J. Gebicke-Haerter (2005) Expression Profiling Methods Used In Drug Abuse Research. Addiction Biol. 10, 37-46.
17. P.J. Gebicke-Haerter (2005) Microarrays and expression profiling in microglia research and in inflammatory brain disorders. J.Neurosci.Res. 81, 327-341.
18. P. J. Gebicke-Haerter (2006) Expression profiling in brain disorders and beyond. Jpn. J. Neuropsychopharmacol. 26, 1-10.
19. P.J. Gebicke-Haerter (2008) Systems biology in molecular psychiatry. Pharmacopsychiatry, in press.
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